Specialized pro-resolving mediators (SPMs) are bioactive lipid mediators that are produced during the resolution phase of inflammation. They play a crucial role in resolving inflammation, promoting tissue repair, and maintaining homeostasis in the body. SPMs are derived from omega-3 fatty acids and include various molecules such as resolvins, protectins, and maresins. Research in the area of SPMs focuses on understanding their mechanisms of action, identifying new SPMs, and developing therapeutic strategies to harness their anti-inflammatory and pro-resolving properties. This research area has the potential to lead to the development of new treatments for chronic inflammatory diseases, such as arthritis, cardiovascular disease, and neurodegenerative disorders.